Take the F train to the Roosevelt Island stop. When exiting the train station, make a left and walk past the Duane Reade and Riverwalk Cafe (away from the Manhattan side of the island, toward the Queens side of the island). When you get to the street, make a left and walk three buildings down to 475 Main St. If coming by tram, exit the tram station via the exit nearest the fountain. Follow the road straight in front of you (it runs parallel to the river, away from the Queensborough bridge behind you) and walk straight, past the green plaza to 475 Main St.